A Promiscuous Conformational Switch in the Secondary Multidrug Transporter MdfA

Multidrug (Mdr) transporters are membrane proteins that actively export structurally dissimilar drugs from the cell, thereby rendering the cell resistant to toxic compounds. Similar to substrate-specific transporters, Mdr transporters also undergo substrate-induced conformational changes. However, t...

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Bibliographic Details
Main Authors: Fluman, Nir, Cohen-Karni, Devora, Weiss, Tali, Bibi, Eitan
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Membrane Transport, Structure, Function, and Biogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781643/
https://ncbi.nlm.nih.gov/pubmed/19808670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.050658
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