Heparan Sulfate Proteoglycan Modulation of Wnt5A Signal Transduction in Metastatic Melanoma Cells

Heparan sulfate proteoglycans (HSPGs) are important modulators for optimizing signal transduction of many pathways, including the Wnt pathways. We demonstrate that HSPG glycosaminoglycan levels increased with increasing metastatic potential of melanoma cells. Previous studies have demonstrated that...

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Bibliographische Detailangaben
Hauptverfasser: O'Connell, Michael P., Fiori, Jennifer L., Kershner, Emily K., Frank, Brittany P., Indig, Fred E., Taub, Dennis D., Hoek, Keith S., Weeraratna, Ashani T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Glycobiology and Extracellular Matrices
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781415/
https://ncbi.nlm.nih.gov/pubmed/19696445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.028498
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