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Determination of the Substrate Binding Mode to the Active Site Iron of (S)-2-Hydroxypropylphosphonic Acid Epoxidase Using (17)O-Enriched Substrates and Substrate Analogues

(S)-2-hydroxypropylphosphonic acid epoxidase (HppE) is an O(2)-dependent, nonheme Fe(II)-containing oxidase that converts (S)-2-hydroxypropylphosphonic acid ((S)-HPP) to the regio-and enantiomerically specific epoxide, fosfomycin. Use of (R)-2-hydroxypropylphosphonic acid ((R)-HPP) yields the 2-keto...

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Detaylı Bibliyografya
Asıl Yazarlar: Yan, Feng, Moon, Sung-Ju, Liu, Pinghua, Zhao, Zongbao, Lipscomb, John D., Liu, Aimin, Liu, Hung-wen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2007
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780580/
https://ncbi.nlm.nih.gov/pubmed/17927218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi701370e
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