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Structure and reactivity of hydroxypropylphosphonic acid epoxidase in fosfomycin biosynthesis by a cation- and flavin-dependent mechanism

The biosynthesis of fosfomycin, an oxirane antibiotic in clinical use, involves a unique epoxidation catalyzed by (S)-2-hydroxypropylphosphonic acid epoxidase (HPPE). The reaction is essentially dehydrogenation of a secondary alcohol. A high-resolution crystallographic analysis reveals that the HPPE...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: McLuskey, Karen, Cameron, Scott, Hammerschmidt, Friedrich, Hunter, William N.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2005
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1234900/
https://ncbi.nlm.nih.gov/pubmed/16186494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504314102
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