Investigations of the Flavin‐Dependent Monooxygenase PhzO Involved in Phenazine Biosynthesis

ABSTRACT Phenazines are bioactive secondary metabolites with antifungal, anticancer, and insecticidal properties, while hydroxylated derivatives often exhibit enhanced bioactivity. 2‐hydroxyphenazine (2‐OH‐PHZ), which is synthesised by the flavin‐dependent monooxygenase PhzO from phenazine‐1‐carboxy...

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Hlavní autoři:	Yan‐Fang Nie, Sheng‐Jie Yue, Peng Huang, Xue‐Hong Zhang, Xiang‐Rui Hao, Lian Jiang, Hong‐Bo Hu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2025-06-01
Edice:	Microbial Biotechnology
Témata:	3,4‐dihydroxy‐phenazine‐1‐carboxylic acid (3,4‐OH‐PCA) anticancer properties flavin reductase Fre monooxygenase PhzO phenazine biocatalysis promiscuous enzymatic activity
On-line přístup:	https://doi.org/10.1111/1751-7915.70186
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