The integrin α(4)β(7) forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1

Both activated and resting CD4(+) T cells in mucosal tissues play important roles in the earliest phases of infection after sexual transmission of HIV-1, a process that is inefficient. HIV-1 gp120 binds to integrin α(4)β(7) (α(4)β(7)), the gut mucosal homing receptor. We find that α(4)β(7)(high) CD4...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cicala, Claudia, Martinelli, Elena, McNally, Jonathan P., Goode, Diana J., Gopaul, Ravindra, Hiatt, Joseph, Jelicic, Katija, Kottilil, Shyamasundaran, Macleod, Katilyn, O'Shea, Angeline, Patel, Nikita, Van Ryk, Donald, Wei, Danlan, Pascuccio, Massimiliano, Yi, Ling, McKinnon, Lyle, Izulla, Preson, Kimani, Joshua, Kaul, Rupert, Fauci, Anthony S., Arthos, James
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2009
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780317/
https://ncbi.nlm.nih.gov/pubmed/19933330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911796106
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