The Genotype of Early-Transmitting HIV gp120s Promotes α(4)β(7) –Reactivity, Revealing α(4)β(7) (+)/CD4(+) T cells As Key Targets in Mucosal Transmission

Mucosal transmission of HIV is inefficient. The virus must breach physical barriers before it infects mucosal CD4(+) T cells. Low-level viral replication occurs initially in mucosal CD4(+) T cells, but within days high-level replication occurs in Peyer's patches, the gut lamina propria and mese...

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Bibliografiske detaljer
Main Authors: Nawaz, Fatima, Cicala, Claudia, Van Ryk, Donald, Block, Katharine E., Jelicic, Katija, McNally, Jonathan P., Ogundare, Olajumoke, Pascuccio, Massimiliano, Patel, Nikita, Wei, Danlan, Fauci, Anthony S., Arthos, James
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044691/
https://ncbi.nlm.nih.gov/pubmed/21383973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001301
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