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The integrin α(4)β(7) forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1
Both activated and resting CD4(+) T cells in mucosal tissues play important roles in the earliest phases of infection after sexual transmission of HIV-1, a process that is inefficient. HIV-1 gp120 binds to integrin α(4)β(7) (α(4)β(7)), the gut mucosal homing receptor. We find that α(4)β(7)(high) CD4...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2780317/ https://ncbi.nlm.nih.gov/pubmed/19933330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911796106 |
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