The integrin α(4)β(7) forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1

Both activated and resting CD4(+) T cells in mucosal tissues play important roles in the earliest phases of infection after sexual transmission of HIV-1, a process that is inefficient. HIV-1 gp120 binds to integrin α(4)β(7) (α(4)β(7)), the gut mucosal homing receptor. We find that α(4)β(7)(high) CD4...

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Detalhes bibliográficos
Main Authors: Cicala, Claudia, Martinelli, Elena, McNally, Jonathan P., Goode, Diana J., Gopaul, Ravindra, Hiatt, Joseph, Jelicic, Katija, Kottilil, Shyamasundaran, Macleod, Katilyn, O'Shea, Angeline, Patel, Nikita, Van Ryk, Donald, Wei, Danlan, Pascuccio, Massimiliano, Yi, Ling, McKinnon, Lyle, Izulla, Preson, Kimani, Joshua, Kaul, Rupert, Fauci, Anthony S., Arthos, James
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780317/
https://ncbi.nlm.nih.gov/pubmed/19933330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911796106
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