The integrin α(4)β(7) forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1

Both activated and resting CD4(+) T cells in mucosal tissues play important roles in the earliest phases of infection after sexual transmission of HIV-1, a process that is inefficient. HIV-1 gp120 binds to integrin α(4)β(7) (α(4)β(7)), the gut mucosal homing receptor. We find that α(4)β(7)(high) CD4...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Cicala, Claudia, Martinelli, Elena, McNally, Jonathan P., Goode, Diana J., Gopaul, Ravindra, Hiatt, Joseph, Jelicic, Katija, Kottilil, Shyamasundaran, Macleod, Katilyn, O'Shea, Angeline, Patel, Nikita, Van Ryk, Donald, Wei, Danlan, Pascuccio, Massimiliano, Yi, Ling, McKinnon, Lyle, Izulla, Preson, Kimani, Joshua, Kaul, Rupert, Fauci, Anthony S., Arthos, James
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2009
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780317/
https://ncbi.nlm.nih.gov/pubmed/19933330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911796106
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge