Characterization of Detergent-Insoluble Proteins in ALS Indicates a Causal Link between Nitrative Stress and Aggregation in Pathogenesis

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive and fatal motor neuron disease, and protein aggregation has been proposed as a possible pathogenetic mechanism. However, the aggregate protein constituents are poorly characterized so knowledge on the role of aggregation in pathogenesi...

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Detalhes bibliográficos
Main Authors: Basso, Manuela, Samengo, Giuseppina, Nardo, Giovanni, Massignan, Tania, D'Alessandro, Giuseppina, Tartari, Silvia, Cantoni, Lavinia, Marino, Marianna, Cheroni, Cristina, De Biasi, Silvia, Giordana, Maria Teresa, Strong, Michael J., Estevez, Alvaro G., Salmona, Mario, Bendotti, Caterina, Bonetto, Valentina
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780298/
https://ncbi.nlm.nih.gov/pubmed/19956584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008130
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