Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis†

In familial and sporadic amyotrophic lateral sclerosis (ALS) and in rodent models of the disease, alterations in the ubiquitin-proteasome system (UPS) may be responsible for the accumulation of potentially harmful ubiquitinated proteins, leading to motor neuron death. In the spinal cord of transgeni...

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Detalhes bibliográficos
Main Authors: Cheroni, Cristina, Marino, Marianna, Tortarolo, Massimo, Veglianese, Pietro, De Biasi, Silvia, Fontana, Elena, Zuccarello, Laura Vitellaro, Maynard, Christa J., Dantuma, Nico P., Bendotti, Caterina
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298865/
https://ncbi.nlm.nih.gov/pubmed/18826962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn319
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