Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (irinotecan; CPT-11) toxicity

CPT-11 is an antitumor prodrug that is hydrolyzed by carboxylesterases (CE) to yield SN-38, a potent topoisomerase I poison. However, the dose limiting toxicity is delayed diarrhea that is thought to arise, in part, from activation of the prodrug by a human intestinal CE (hiCE). Therefore, we have s...

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Bibliographic Details
Main Authors: Hicks, Latorya D., Hyatt, Janice L, Stoddard, Shana, Tsurkan, Lyudmila, Edwards, Carol C., Wadkins, Randy M., Potter, Philip M.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780016/
https://ncbi.nlm.nih.gov/pubmed/19534556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9001296
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