A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization

Numerous mutations in the human A-type lamin gene (LMNA) cause the premature aging disease, progeria. Some of these are located in the α-helical central rod domain required for the polymerization of the nuclear lamins into higher order structures. Patient cells with a mutation in this domain, 433G&g...

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Autors principals: Taimen, Pekka, Pfleghaar, Katrin, Shimi, Takeshi, Möller, Dorothee, Ben-Harush, Kfir, Erdos, Michael R., Adam, Stephen A., Herrmann, Harald, Medalia, Ohad, Collins, Francis S., Goldman, Anne E., Goldman, Robert D.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779830/
https://ncbi.nlm.nih.gov/pubmed/19926845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911895106
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