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Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin
Thrombin is a multifunctional protease that plays a key role in hemostasis, thrombosis, and inflammation. Most thrombin inhibitors currently used as antithrombotic agents target thrombin's active site and inhibit all of its myriad of activities. Exosites 1 and 2 are distinct regions on the surf...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Cold Spring Harbor Laboratory Press
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2779679/ https://ncbi.nlm.nih.gov/pubmed/19846574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1240109 |
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