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The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure

The 5′-end of the flavivirus genome harbors a methylated (m7)GpppA(2′OMe) cap structure, which is generated by the virus-encoded RNA triphosphatase, RNA (guanine-N7) methyltransferase, nucleoside 2′-O-methyltransferase, and RNA guanylyltransferase. The presence of the flavivirus guanylyltransferase...

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Autors principals: Issur, Moheshwarnath, Geiss, Brian J., Bougie, Isabelle, Picard-Jean, Frédéric, Despins, Simon, Mayette, Joannie, Hobdey, Sarah E., Bisaillon, Martin
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779676/
https://ncbi.nlm.nih.gov/pubmed/19850911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1609709
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