Design, Synthesis, and X-ray Crystal Structures of 2,4-Diaminofuro[2,3-d]pyrimidines as Multireceptor Tyrosine Kinase and Dihydrofolate Reductase Inhibitors

Registos relacionados

• The Z isomer of 2,4-diaminofuro[2,3-d]pyrimidine antifolate promotes unusual crystal packing in a human dihydrofolate reductase ternary complex
  Por: Cody, Vivian, et al.
  Publicado em: (2009)
• Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection
  Por: Khushbu, Shah, et al.
  Publicado em: (2019)
• Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-­diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase
  Por: Cody, Vivian, et al.
  Publicado em: (2010)
• Targeting Species Specific Amino Acid Residues: Design, Synthesis and Biological Evaluation of 6-Substituted Pyrrolo[2,3-d]pyrimidines as Dihydrofolate Reductase Inhibitors and Potential Anti-Opportunistic Infection Agents
  Por: Shah, Khushbu, et al.
  Publicado em: (2018)
• Structure–activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase
  Por: Cody, Vivian, et al.
  Publicado em: (2015)