The CEACAM1 N-terminal Ig domain mediates cis- and trans-binding and is essential for allosteric rearrangements of CEACAM1 microclusters

Cell adhesion molecules (CAMs) sense the extracellular microenvironment and transmit signals to the intracellular compartment. In this investigation, we addressed the mechanism of signal generation by ectodomains of single-pass transmembrane homophilic CAMs. We analyzed the structure and homophilic...

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Detalhes bibliográficos
Main Authors: Klaile, Esther, Vorontsova, Olga, Sigmundsson, Kristmundur, Müller, Mario M., Singer, Bernhard B., Öfverstedt, Lars-Göran, Svensson, Stina, Skoglund, Ulf, Öbrink, Björn
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779236/
https://ncbi.nlm.nih.gov/pubmed/19948502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200904149
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