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A minimal sequence code for switching protein structure and function
We present here a structural and mechanistic description of how a protein changes its fold and function, mutation by mutation. Our approach was to create 2 proteins that (i) are stably folded into 2 different folds, (ii) have 2 different functions, and (iii) are very similar in sequence. In this sim...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2009
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2779201/ https://ncbi.nlm.nih.gov/pubmed/19923431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906408106 |
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