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NMR structures of two designed proteins with high sequence identity but different fold and function

How protein sequence codes for 3D structure remains a fundamental question in biology. One approach to understanding the folding code is to design a pair of proteins with maximal sequence identity but retaining different folds. Therefore, the nonidentities must be responsible for determining which f...

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Autori principali: He, Yanan, Chen, Yihong, Alexander, Patrick, Bryan, Philip N., Orban, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567172/
https://ncbi.nlm.nih.gov/pubmed/18796611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805857105
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