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Subdomain Interactions Foster the Design of Two Protein Pairs with ∼80% Sequence Identity but Different Folds

Metamorphic proteins, including proteins with high levels of sequence identity but different folds, are exceptions to the long-standing rule-of-thumb that proteins with as little as 30% sequence identity adopt the same fold. Which topologies can be bridged by these highly identical sequences remains...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Porter, Lauren L., He, Yanan, Chen, Yihong, Orban, John, Bryan, Philip N.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286614/
https://ncbi.nlm.nih.gov/pubmed/25564862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.10.073
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