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A minimal sequence code for switching protein structure and function

We present here a structural and mechanistic description of how a protein changes its fold and function, mutation by mutation. Our approach was to create 2 proteins that (i) are stably folded into 2 different folds, (ii) have 2 different functions, and (iii) are very similar in sequence. In this sim...

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Autors principals: Alexander, Patrick A., He, Yanan, Chen, Yihong, Orban, John, Bryan, Philip N.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779201/
https://ncbi.nlm.nih.gov/pubmed/19923431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906408106
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