The evolution of pandemic and non-pandemic HIV-1 strains has been driven by Tetherin antagonism

Vpu proteins of pandemic HIV-1 M strains degrade the viral receptor CD4 and antagonize human tetherin to promote viral release and replication. We find that Vpus from SIVgsn, SIVmus and SIVmon infecting Cercopithecus primate species also degrade CD4 and antagonize tetherin. In contrast, SIVcpz, the...

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Autors principals: Sauter, Daniel, Schindler, Michael, Specht, Anke, Landford, Wilmina N., Münch, Jan, Kim, Kyeong-Ae, Votteler, Jörg, Schubert, Ulrich, Bibollet-Ruche, Frederic, Keele, Brandon F., Takehisa, Jun, Ogando, Yudelca, Ochsenbauer, Christina, Kappes, John C., Ayouba, Ahidjo, Peeters, Martine, Learn, Gerald H., Shaw, George, Sharp, Paul M., Bieniasz, Paul, Hahn, Beatrice H., Hatziioannou, Theodora, Kirchhoff, Frank
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779047/
https://ncbi.nlm.nih.gov/pubmed/19917496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2009.10.004
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