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Preclinical activity of 8-chloroadenosine with mantle cell lymphoma: Roles of energy depletion and inhibition of DNA and RNA synthesis

8-Chloroadenosine (8-Cl-Ado), an RNA-directed nucleoside analog, is currently being evaluated in phase I clinical trials for treatment of chronic lymphocytic leukemia. In the current study, the efficacy of 8-Cl-Ado was evaluated using mantle cell lymphoma (MCL) cell lines: Granta 519, JeKo, Mino, an...

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Autors principals: Dennison, Jennifer B., Balakrishnan, Kumudha, Gandhi, Varsha
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778754/
https://ncbi.nlm.nih.gov/pubmed/19709085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2009.07850.x
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