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Cilia localization is essential for in vivo functions of the Joubert syndrome protein Arl13b/Scorpion
arl13b was initially cloned as the novel cystic kidney gene scorpion (sco) in zebrafish and was shown to be required for cilia formation in the kidney duct. In mouse, a null mutant of Arl13b shows abnormal ultrastructure of the cilium and defective sonic hedgehog (Shh) signaling. Importantly, a rece...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Company of Biologists
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2778746/ https://ncbi.nlm.nih.gov/pubmed/19906870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.036350 |
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