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Cilia localization is essential for in vivo functions of the Joubert syndrome protein Arl13b/Scorpion

arl13b was initially cloned as the novel cystic kidney gene scorpion (sco) in zebrafish and was shown to be required for cilia formation in the kidney duct. In mouse, a null mutant of Arl13b shows abnormal ultrastructure of the cilium and defective sonic hedgehog (Shh) signaling. Importantly, a rece...

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Detalhes bibliográficos
Main Authors: Duldulao, Neil A., Lee, Sunjin, Sun, Zhaoxia
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778746/
https://ncbi.nlm.nih.gov/pubmed/19906870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.036350
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