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Crystal structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine

ClpX is a AAA+ machine that uses the energy of ATP binding and hydrolysis to unfold native proteins and translocate unfolded polypeptides into the ClpP peptidase. The crystal structures presented here reveal striking asymmetry in ring hexamers of nucleotide-free and nucleotide-bound ClpX. Asymmetry...

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Bibliografske podrobnosti
Main Authors: Glynn, Steven E., Martin, Andreas, Nager, Andrew R., Baker, Tania A., Sauer, Robert T.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778613/
https://ncbi.nlm.nih.gov/pubmed/19914167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.09.034
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