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Chloroquine Transport in Plasmodium falciparum II: Analysis of PfCRT Mediated Drug Transport Using Proteoliposomes and a Fluorescent Chloroquine Probe

Mutations in the PfCRT protein cause chloroquine resistance (CQR) and earlier studies from our laboratory using plasma membrane inside-out vesicles (ISOV) prepared from yeast expressing recombinant PfCRT [Zhang, H., et al. (2004) Biochemistry 43, 8290–8296] suggested that the putative transporter me...

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Main Authors: Paguio, Michelle F., Cabrera, Mynthia, Roepe, Paul D.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778255/
https://ncbi.nlm.nih.gov/pubmed/19725576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901035j
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