Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress

ATR is an essential kinase activated in response to DNA-replication stress, with a known target being the RPA2 subunit of human replication protein A (RPA). We find that S33-RPA2 phosphorylation by ATR occurs primarily in the late-S and G2 phases, probably at sites of residual stalled DNA-replicatio...

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Main Authors: Vassin, Vitaly M., Anantha, Rachel William, Sokolova, Elena, Kanner, Shlomo, Borowiec, James A.
Format: Artigo
Jezik:Inglês
Izdano: Company of Biologists 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776501/
https://ncbi.nlm.nih.gov/pubmed/19843584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.053702
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