ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA

The ataxia telangiectasia-mutated and Rad3-related (ATR) kinase checkpoint pathway maintains genome integrity; however, the role of the sirtuin 2 (SIRT2) acetylome in regulating this pathway is not clear. We found that deacetylation of ATR-interacting protein (ATRIP), a regulatory partner of ATR, by...

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Vydáno v:Cell Rep
Hlavní autoři: Zhang, Hui, Head, PamelaSara E., Daddacha, Waaqo, Park, Seong-Hoon, Li, Xingzhe, Pan, Yunfeng, Madden, Matthew Z., Duong, Duc M., Xie, Maohua, Yu, Bing, Warren, Matthew D., Liu, Elaine A., Dhere, Vishal R., Li, Chunyang, Pradilla, Ivan, Torres, Mylin A., Wang, Ya, Dynan, William S., Doetsch, Paul W., Deng, Xingming, Seyfried, Nicholas T., Gius, David, Yu, David S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758896/
https://ncbi.nlm.nih.gov/pubmed/26854234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.01.018
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