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Asymmetric Deactivation of HIV-1 gp41 following Fusion Inhibitor Binding
Both equilibrium and nonequilibrium factors influence the efficacy of pharmaceutical agents that target intermediate states of biochemical reactions. We explored the intermediate state inhibition of gp41, part of the HIV-1 envelope glycoprotein complex (Env) that promotes viral entry through membran...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2776349/ https://ncbi.nlm.nih.gov/pubmed/19956769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000674 |
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