Asymmetric Deactivation of HIV-1 gp41 following Fusion Inhibitor Binding

Both equilibrium and nonequilibrium factors influence the efficacy of pharmaceutical agents that target intermediate states of biochemical reactions. We explored the intermediate state inhibition of gp41, part of the HIV-1 envelope glycoprotein complex (Env) that promotes viral entry through membran...

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Bibliographic Details
Main Authors: Kahle, Kristen M., Steger, H. Kirby, Root, Michael J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776349/
https://ncbi.nlm.nih.gov/pubmed/19956769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000674
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