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Tetracycline-Tet Repressor Binding Specificity: Insights from Experiments and Simulations

Tetracycline (Tc) antibiotics have been put to new uses in the construction of artificial gene regulation systems, where they bind to the Tet repressor protein (TetR) and modulate its affinity for DNA. Many Tc variants have been produced, both to overcome bacterial resistance and to achieve a broad...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Aleksandrov, Alexey, Schuldt, Linda, Hinrichs, Winfried, Simonson, Thomas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Biophysical Society 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776281/
https://ncbi.nlm.nih.gov/pubmed/19917238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.08.050
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