Tetracycline-Tet Repressor Binding Specificity: Insights from Experiments and Simulations

Tetracycline (Tc) antibiotics have been put to new uses in the construction of artificial gene regulation systems, where they bind to the Tet repressor protein (TetR) and modulate its affinity for DNA. Many Tc variants have been produced, both to overcome bacterial resistance and to achieve a broad...

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Hlavní autoři: Aleksandrov, Alexey, Schuldt, Linda, Hinrichs, Winfried, Simonson, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2009
Témata:
Protein
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776281/
https://ncbi.nlm.nih.gov/pubmed/19917238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.08.050
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