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Molecular Dynamics Simulations Show That Conformational Selection Governs the Binding Preferences of Imatinib for Several Tyrosine Kinases

Tyrosine kinases transmit cellular signals through a complex mechanism, involving their phosphorylation and switching between inactive and active conformations. The cancer drug imatinib binds tightly to several homologous kinases, including Abl, but weakly to others, including Src. Imatinib specific...

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Bibliografiset tiedot
Päätekijät: Aleksandrov, Alexey, Simonson, Thomas
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2010
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859544/
https://ncbi.nlm.nih.gov/pubmed/20200154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.109660
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