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Tetracycline-Tet Repressor Binding Specificity: Insights from Experiments and Simulations
Tetracycline (Tc) antibiotics have been put to new uses in the construction of artificial gene regulation systems, where they bind to the Tet repressor protein (TetR) and modulate its affinity for DNA. Many Tc variants have been produced, both to overcome bacterial resistance and to achieve a broad...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Biophysical Society
2009
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2776281/ https://ncbi.nlm.nih.gov/pubmed/19917238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.08.050 |
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