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Tetracycline-Tet Repressor Binding Specificity: Insights from Experiments and Simulations
Tetracycline (Tc) antibiotics have been put to new uses in the construction of artificial gene regulation systems, where they bind to the Tet repressor protein (TetR) and modulate its affinity for DNA. Many Tc variants have been produced, both to overcome bacterial resistance and to achieve a broad...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2776281/ https://ncbi.nlm.nih.gov/pubmed/19917238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.08.050 |
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