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Effect of N-acetylcysteine route of administration on chemoprotection against cisplatin-induced toxicity in rat models

Dosing and route of administration of N-acetylcysteine (NAC) for protection against cisplatin (CDDP) nephrotoxicity was investigated in rats. Two models of toxicity were tested: a single high dose of CDDP (10 mg/kg intraperitoneally (IP)), and multiple low dose treatments (1 mg/kg IP twice a day for...

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Huvudupphovsmän: Dickey, D. Thomas, Muldoon, Leslie L., Doolittle, Nancy D., Peterson, Darryl R., Kraemer, Dale F., Neuwelt, Edward A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2007
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776068/
https://ncbi.nlm.nih.gov/pubmed/17909806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-007-0597-2
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