Early-Onset and Robust Amyloid Pathology in a New Homozygous Mouse Model of Alzheimer's Disease

BACKGROUND: Transgenic mice expressing mutated amyloid precursor protein (APP) and presenilin (PS)-1 or -2 have been successfully used to model cerebral β-amyloidosis, one of the characteristic hallmarks of Alzheimer's disease (AD) pathology. However, the use of many transgenic lines is limited...

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Autori principali: Willuweit, Antje, Velden, Joachim, Godemann, Robert, Manook, Andre, Jetzek, Fritz, Tintrup, Hartmut, Kauselmann, Gunther, Zevnik, Branko, Henriksen, Gjermund, Drzezga, Alexander, Pohlner, Johannes, Schoor, Michael, Kemp, John A., von der Kammer, Heinz
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775952/
https://ncbi.nlm.nih.gov/pubmed/19936202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007931
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