Small-Animal PET Imaging of Amyloid-Beta Plaques with [(11)C]PiB and Its Multi-Modal Validation in an APP/PS1 Mouse Model of Alzheimer's Disease

In vivo imaging and quantification of amyloid-β plaque (Aβ) burden in small-animal models of Alzheimer's disease (AD) is a valuable tool for translational research such as developing specific imaging markers and monitoring new therapy approaches. Methodological constraints such as image resolut...

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Bibliographic Details
Main Authors: Manook, André, Yousefi, Behrooz H., Willuweit, Antje, Platzer, Stefan, Reder, Sybille, Voss, Andreas, Huisman, Marc, Settles, Markus, Neff, Frauke, Velden, Joachim, Schoor, Michael, von der Kammer, Heinz, Wester, Hans-Jürgen, Schwaiger, Markus, Henriksen, Gjermund, Drzezga, Alexander
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302888/
https://ncbi.nlm.nih.gov/pubmed/22427802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031310
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