Hybrid Embryonic Stem Cell-Derived Tetraploid Mice Show Apparently Normal Morphological, Physiological, and Neurological Characteristics

ES cell-tetraploid (ES) mice are completely derived from embryonic stem cells and can be obtained at high efficiency upon injection of hybrid ES cells into tetraploid blastocysts. This method allows the immediate generation of targeted mouse mutants from genetically modified ES cell clones, in contr...

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Autors principals: Schwenk, Frieder, Zevnik, Branko, Brüning, Jens, Röhl, Mathias, Willuweit, Antje, Rode, Anja, Hennek, Thomas, Kauselmann, Gunther, Jaenisch, Rudolf, Kühn, Ralf
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC155215/
https://ncbi.nlm.nih.gov/pubmed/12748299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.11.3982-3989.2003
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