Hybrid Embryonic Stem Cell-Derived Tetraploid Mice Show Apparently Normal Morphological, Physiological, and Neurological Characteristics

ES cell-tetraploid (ES) mice are completely derived from embryonic stem cells and can be obtained at high efficiency upon injection of hybrid ES cells into tetraploid blastocysts. This method allows the immediate generation of targeted mouse mutants from genetically modified ES cell clones, in contr...

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Bibliographische Detailangaben
Hauptverfasser: Schwenk, Frieder, Zevnik, Branko, Brüning, Jens, Röhl, Mathias, Willuweit, Antje, Rode, Anja, Hennek, Thomas, Kauselmann, Gunther, Jaenisch, Rudolf, Kühn, Ralf
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC155215/
https://ncbi.nlm.nih.gov/pubmed/12748299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.11.3982-3989.2003
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