Hybrid Embryonic Stem Cell-Derived Tetraploid Mice Show Apparently Normal Morphological, Physiological, and Neurological Characteristics

ES cell-tetraploid (ES) mice are completely derived from embryonic stem cells and can be obtained at high efficiency upon injection of hybrid ES cells into tetraploid blastocysts. This method allows the immediate generation of targeted mouse mutants from genetically modified ES cell clones, in contr...

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Bibliografiske detaljer
Main Authors: Schwenk, Frieder, Zevnik, Branko, Brüning, Jens, Röhl, Mathias, Willuweit, Antje, Rode, Anja, Hennek, Thomas, Kauselmann, Gunther, Jaenisch, Rudolf, Kühn, Ralf
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC155215/
https://ncbi.nlm.nih.gov/pubmed/12748299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.11.3982-3989.2003
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