Anthrax Lethal Toxin Induced Lysosomal Membrane Permeabilization and Cytosolic Cathepsin Release Is Nlrp1b/Nalp1b-Dependent

NOD-like receptors (NLRs) are a group of cytoplasmic molecules that recognize microbial invasion or ‘danger signals’. Activation of NLRs can induce rapid caspase-1 dependent cell death termed pyroptosis, or a caspase-1 independent cell death termed pyronecrosis. Bacillus anthracis lethal toxin (LT),...

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Autori principali: Averette, Kathleen M., Pratt, Matthew R., Yang, Yanan, Bassilian, Sara, Whitelegge, Julian P., Loo, Joseph A., Muir, Tom W., Bradley, Kenneth A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775945/
https://ncbi.nlm.nih.gov/pubmed/19924255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007913
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