Sub-lethal oxidative stress induces lysosome biogenesis via a lysosomal membrane permeabilization-cathepsin-caspase 3-transcription factor EB-dependent pathway

Here we provide evidence to link sub-lethal oxidative stress to lysosome biogenesis. Exposure of cells to sub-lethal concentrations of exogenously added hydrogen peroxide resulted in cytosol to nuclear translocation of the Transcription Factor EB (TFEB), the master controller of lysosome biogenesis...

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Publicat a:Oncotarget
Autors principals: Leow, San Min, Chua, Shu Xian Serene, Venkatachalam, Gireedhar, Shen, Liang, Luo, Le, Clement, Marie-Veronique
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper: Autophagy and Cell Death
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5369955/
https://ncbi.nlm.nih.gov/pubmed/28002813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14016
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