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Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling

The kinetics and magnitude of cytokine gene expression are tightly regulated to elicit a balanced response to pathogens and result from integrated changes in transcription and mRNA stability. Yet, how a single microbial stimulus induces peak transcription of some genes (TNFα) within minutes whereas...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Adelman, Karen, Kennedy, Megan A., Nechaev, Sergei, Gilchrist, Daniel A., Muse, Ginger W., Chinenov, Yurii, Rogatsky, Inez
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775335/
https://ncbi.nlm.nih.gov/pubmed/19820169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910177106
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