Paddling mechanism for the substrate translocation by AAA+ motor revealed by multiscale molecular simulations

Hexameric ring-shaped AAA+ molecular motors have a key function of active translocation of a macromolecular chain through the central pore. By performing multiscale molecular dynamics (MD) simulations, we revealed that HslU, a AAA+ motor in a bacterial homologue of eukaryotic proteasome, translocate...

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Bibliographic Details
Main Authors: Koga, Nobuyasu, Kameda, Tomoshi, Okazaki, Kei-ichi, Takada, Shoji
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775326/
https://ncbi.nlm.nih.gov/pubmed/19828442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904756106
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