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Paddling mechanism for the substrate translocation by AAA+ motor revealed by multiscale molecular simulations
Hexameric ring-shaped AAA+ molecular motors have a key function of active translocation of a macromolecular chain through the central pore. By performing multiscale molecular dynamics (MD) simulations, we revealed that HslU, a AAA+ motor in a bacterial homologue of eukaryotic proteasome, translocate...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2775326/ https://ncbi.nlm.nih.gov/pubmed/19828442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904756106 |
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