Transient structural distortion of metal-free Cu/Zn superoxide dismutase triggers aberrant oligomerization

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease linked to the misfolding of Cu/Zn superoxide dismutase (SOD1). ALS-related defects in SOD1 result in a gain of toxic function that coincides with aberrant oligomerization. The structural events triggering oligomerization have remaine...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Teilum, Kaare, Smith, Melanie H., Schulz, Eike, Christensen, Lea C., Solomentsev, Gleb, Oliveberg, Mikael, Akke, Mikael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2009
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775296/
https://ncbi.nlm.nih.gov/pubmed/19828437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907387106
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg