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Transient structural distortion of metal-free Cu/Zn superoxide dismutase triggers aberrant oligomerization
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease linked to the misfolding of Cu/Zn superoxide dismutase (SOD1). ALS-related defects in SOD1 result in a gain of toxic function that coincides with aberrant oligomerization. The structural events triggering oligomerization have remaine...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2775296/ https://ncbi.nlm.nih.gov/pubmed/19828437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907387106 |
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