Transient structural distortion of metal-free Cu/Zn superoxide dismutase triggers aberrant oligomerization

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease linked to the misfolding of Cu/Zn superoxide dismutase (SOD1). ALS-related defects in SOD1 result in a gain of toxic function that coincides with aberrant oligomerization. The structural events triggering oligomerization have remaine...

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Autores principales: Teilum, Kaare, Smith, Melanie H., Schulz, Eike, Christensen, Lea C., Solomentsev, Gleb, Oliveberg, Mikael, Akke, Mikael
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2009
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775296/
https://ncbi.nlm.nih.gov/pubmed/19828437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907387106
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