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Zyklophin, a systemically active selective kappa opioid receptor peptide antagonist with short duration of action
The cyclic peptide zyklophin {[N-benzylTyr(1),cyclo(D-Asp(5),Dap(8))-dynorphin A-(1–11)NH(2), Patkar KA, et al. (2005) J Med Chem 48: 4500–4503} is a selective peptide kappa opioid receptor (KOR) antagonist that shows activity following systemic administration. Systemic (1–3 mg/kg s.c.) as well as c...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2775281/ https://ncbi.nlm.nih.gov/pubmed/19841255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910180106 |
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