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Apoptotic Signaling Activated by Modulation of the F(0)F(1)-ATPase: Implications for Selective Killing of Autoimmune Lymphocytes
7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(napthalen-2-ylmetyl)-4,5,-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one (Bz-423) is a proapoptotic 1,4-benzodiazepine that potently suppresses disease in the murine model of lupus by selectively killing pathogenic lymphocytes. In MRL/MpJ-Fas(lpr) (MRL-lpr) mice,...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The American Society for Pharmacology and Experimental Therapeutics
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2775264/ https://ncbi.nlm.nih.gov/pubmed/19706792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.156422 |
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