Anaplerotic Metabolism of Alloreactive T Cells Provides a Metabolic Approach To Treat Graft-Versus-Host Disease

T-cell activation requires increased ATP and biosynthesis to support proliferation and effector function. Most models of T-cell activation are based on in vitro culture systems and posit that aerobic glycolysis is employed to meet increased energetic and biosynthetic demands. By contrast, T cells ac...

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Bibliographic Details
Main Authors: Glick, Gary D., Rossignol, Rodrigue, Lyssiotis, Costas A., Wahl, Daniel, Lesch, Charles, Sanchez, Brian, Liu, Xikui, Hao, Ling-Yang, Taylor, Clarke, Hurd, Alexander, Ferrara, James L. M., Tkachev, Victor, Byersdorfer, Craig A., Boros, Laszlo, Opipari, Anthony W.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2014
Subjects:
Inflammation, Immunopharmacology, and Asthma
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201277/
https://ncbi.nlm.nih.gov/pubmed/25125579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.218099
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